The effect of hyaluronidase on embryonic chicken skin and mouse oral mucosa has been studied in vitro. Autoradiographic studies showed that .05% hyaluronidase increased the epithelial mitotic index while liquid scintillation techniques demonstrated that hyaluronidase increased the uptake of tritiated thymidine in chicken skin in vitro. Further experiments demonstrated that .05% hyaluronidase interferes with the keratinization process in embryonic chicken skin and mouse oral mucosa in vitro.
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P. B. Innes (1974) studied this question.
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