Key result
These commentaries discuss recent findings on G protein-independent signaling by the angiotensin II type 1 receptor in vivo and the variable phenotypic expression of RAG1 mutations.
Population
Mouse heart model
Comparison
Cardiac-specific overexpression of AT1-i2m vs Cardiac-specific overexpression of AT1-WT
Design
Editorial
Authors
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This commentary highlights the first in vivo evidence that 7-transmembrane receptors like AT1R can signal independently of G proteins, presenting novel therapeutic opportunities for biased agonists.
This commentary highlights the first in vivo evidence that 7-transmembrane receptors like AT1R can signal independently of G proteins, presenting novel therapeutic opportunities for biased agonists.
Keshava Rajagopal (2005) reported an editorial. These commentaries discuss recent findings on G protein-independent signaling by the angiotensin II type 1 receptor in vivo and the variable phenotypic expression of RAG1 mutations.
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