April 1, 1989Journal of Cellular Physiology

Platelet‐derived growth factor and angiotensin II cause increases in cytosolic free calcium by different mechanisms in vascular smooth muscle cells

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Population

Vascular smooth muscle cells (VSMCs)

Design

Preclinical

Authors

MRMichael W. RoeSUNY Upstate Medical University JHJohn R. HeplerEmory University THT. Kendall HardenUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Supports selective targeting of calcium influx in PDGF-driven proliferation; leaves open clinical translation from animal models.

Structured PICO

Population

Vascular smooth muscle cells (VSMCs)

Intervention

Platelet-derived growth factor (PDGF) and angiotensin II (AII)

Outcome

Alterations in cytosolic free calcium ([Ca2+]i)surrogate

PDGF and angiotensin II increase cytosolic free calcium in vascular smooth muscle cells through distinct mechanisms, with PDGF requiring calcium influx for mitogenesis.

Cite This Study

Roe et al. (1989) studied this question.

synapsesocial.com/papers/6a8ad9bdf19228bbb2fb3a72 https://doi.org/10.1002/jcp.1041390115

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