Why the study?
Does propranolol prevent syncope and cardiac arrhythmias in patients with disordered sympathetic innervation of the heart?
Does propranolol prevent syncope and cardiac arrhythmias in patients with disordered sympathetic innervation of the heart?
Cardiac arrhythmias due to disordered sympathetic innervation can present as exercise-induced syncope misdiagnosed as epilepsy, and can be successfully treated with propranolol.
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Propranolol may control syncope and arrhythmias in disordered sympathetic innervation; leaves open need for controlled trials before wider use.
A mother and three children presenting with syncope induced by exercise and emotion were diagnosed as epileptic. They, and three symptom free children, showed frequent ventricular and supraventricular tachyarrhythmias on ambulatory electrocardiographic monitoring. Three died before the correct diagnosis of disordered sympathetic innervation of the heart was made, but episodes of syncope and cardiac arrhythmias in the survivors have been successfully treated by propranolol.
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Rutter et al. (1985) studied this question.
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