A rainbow trout population of infectious pancreatic necrosis virus carriers was studied over a one‐year period using both homogenization and co‐cultivation for virus isolation. The percentage of virus‐yielding fish was high between March and June, but declined during the latter part of the year. This was diametrically opposite to the trend in the serum antibody levels indicating that the marked humoral immune response resulted in a very significant reduction in the virus titres. The highest isolation rate was obtained from the kidneys after co‐cultivation underlining the very high sensitivity of this method for virus detection. Virus was occasionally isolated from the faeces indicating that this may well be a possible avenue for horizontal transmission of the virus. No virus was ever detected in gonadal tissue; the mechanism of vertical transmission of the virus is still very poorly understood.
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Mangunwiryo et al. (1988) studied this question.
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