Studies in Multiple Sclerosis

Article1 January 1936STUDIES IN MULTIPLE SCLEROSISVIII. ETIOLOGIC FACTORS IN MULTIPLE SCLEROSIS*TRACY J. PUTNAM, M.D.TRACY J. PUTNAM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-7-854 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTHE EXPERIMENTAL PRODUCTION OF LESIONS SIMULATING MULTIPLE SCLEROSISIn previous communications, it has been pointed out that lesions closely resembling typical plaques of multiple sclerosis may be produced in animals in either of two ways: by the subcutaneous injection of minute doses of tetanus toxin1and by experimental obstruction of cerebral venules.2In each case sclerotic lesions could be demonstrated only after an interval of several months from the original injury. The earlier lesions closely resembled those of "post-infectious encephalomyelitis," a disease occasionally seen following measles3and vaccinia4and often without obvious antecedent. Areas of demyelination, with relative persistence of...References1. PUTNAMMCKENNAEVANS TJJBJ: Experimental multiple sclerosis in dogs from injection of tetanus toxin, Jr. f. Psychol. u. Neurol., 1932, iv, 460-467. Google Scholar2. PUTNAM TJ: "Encephalitis" and sclerotic plaques from experimental venular obstruction, Arch. Neurol. and Psychiat. (In press.) Google Scholar3. FERRAROSCHEFFER AJH: Encephalitis and encephalomyelitis in measles: a pathologic report of six cases, Arch. Neurol. and Psychiat., 1931, xxv, 748-782. CrossrefGoogle Scholar4. HASSINGEIGER GBJP: Postvaccinal (cowpox) encephalitis, Arch. Neurol. and Psychiat., 1930, xxiii, 481-493. CrossrefGoogle Scholar5. MEYER H: Experimentelle Erfahrungen über die Kohlenoxydvergiftung des Zentralnervensystems, Ztschr. f. d. ges. Neurol. u. 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Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication October 3, 1935. (Presented before the Section of Nervous and Mental Diseases of the American Medical Association, Atlantic City, June 12, 1935.)From the Neurological Unit, Boston City Hospital and the Department of Neurology, Harvard Medical School, Boston, Massachusetts.The expenses of this investigation were defrayed in part by the Multiple Sclerosis Fund of Harvard University. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByBEHAVIOUR OF BLOOD-PLATELETS IN MULTIPLE SCLEROSISMultiple SkleroseBLOOD COAGULATION STUDIES AND SEROTONIN DETERMINATIONS IN SERUM AND CEREBROSPINAL FLUID IN MULTIPLE SCLEROSISDiagnosis of Multiple SclerosisManagement of Multiple SclerosisData on the Pathology of Disseminated SclerosisThe Blood Supply of the Optic Nerve and Its Clinical SignificanceSUPRAVITAL ANALYSIS OF DISORDERS IN THE CEREBRAL VASCULAR PERMEABILITY II. TWO CASES OF MULTIPLE SCLEROSIS 1 January 1936Volume 9, Issue 7Page: 854-863KeywordsEncephalomyelitisLesionsMultiple sclerosisNeurologySubcutaneous injectionsTetanus Issue Published: 1 January 1936 PDF DownloadLoading ...