Summary: A poly(N‐isopropylacrylamide) (PNIPAAm)‐like biodegradable thermosensitive polydepsipeptide, poly[Glc‐Asn(N‐isopropyl)], was synthesized by introducing an isopropyl amide group into poly[Glc‐Asn]. Poly[Glc‐Asn(N‐isopropyl)] was degraded in vitro by cleavage of the ester bonds in the main chain in water at room temperature. The non‐toxic nature of the polymer and its degradation products, coupled with a cloud point at 29 °C in water, make this polymer attractive for biomedical implant applications. The effect of the temperature on the light transmittance of a poly[Glc‐Asn(N‐isopropyl)] solution. magnified image The effect of the temperature on the light transmittance of a poly[Glc‐Asn(N‐isopropyl)] solution.
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Ohya et al. (2005) studied this question.
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