The Subcellular Localization of Virus-specific RNA in Influenza Virus-infected Cells

SUMMARY The synthesis of complementary RNA (cRNA) precedes that of virus particle RNA (vRNA) in fowl plague virus-infected cells. Early cRNA synthesis occurs in the cytoplasm, while the later vRNA synthesis is a nuclear event. Influenza RNA synthesized in infected cells does not contain poly A sequences, as judged by binding to nitrocellulose filters under controlled conditions.