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August 1, 1988Acta Physiologica Scandinavica

Increase in proximal tubular fluid reabsorption by renal nerve stimulation. A split oil droplet study

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Why the study?

Does renal sympathetic nerve stimulation increase proximal tubular fluid reabsorption in anaesthetized male Sprague-Dawley rats?

Population

Anaesthetized male Sprague-Dawley rats (n=9)

Comparison

Direct renal sympathetic nerve stimulation with… vs Control situation (no stimulation)

Design

Preclinical

Authors

AGANN GÖRANSSONUppsala UniversityHUH. R. UlfendahlCzech Academy of Sciences, Institute of Physiology

Discussion

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Overview

Sympathetic enhancement of proximal reabsorption in rats; leaves open its role in human volume homeostasis.

Structured PICO

Does renal sympathetic nerve stimulation increase proximal tubular fluid reabsorption in anaesthetized male Sprague-Dawley rats?

P
Population
Anaesthetized male Sprague-Dawley rats (n=9)
I
Intervention
Direct renal sympathetic nerve stimulation with a frequency of 2 Hz
C
Comparator
Control situation (no stimulation)
O
Outcome
Fluid reabsorption determined as the half-time (t1/2) of the shrinking droplet using a split oil droplet techniquesurrogate

Renal sympathetic nerve stimulation directly increases proximal tubular fluid reabsorption in rats, supporting its role in extracellular volume control.

Cite This Study

GÖRANSSON et al. (1988) studied this question.

synapsesocial.com/papers/6a8ae243fdccabdd22b1e204https://doi.org/10.1111/j.1748-1716.1988.tb08428.x
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of Peritubular Hydrostatic and Oncotic Pressures on Fluid Reabsorption in Proximal Tubules of the Rat Kidney1975 · 16 citations
  2. 2Specificity of Neural Effect on Renal Tubular Sodium Reabsorption1976 · 41 citations
  3. 3Angiotensin II in antinatriuresis of low-level renal nerve stimulation1976 · 32 citations