June 2, 1996European Heart Journal
Effects of A1 adenosine receptor blockade by bamiphylline on ischaemic preconditioning during coronary angioplasty
Why the study?
Does bamiphylline abolish ischaemic preconditioning in patients undergoing single-vessel coronary angioplasty?
Population
36 consecutive patients undergoing single-vessel coronary angioplasty
Comparison
Intravenous infusion of bamiphylline immediately… vs Intravenous infusion of placebo immediately…
Design
RCT, randomized
Follow-up
During the procedure (end of second balloon inflation)
Authors
Discussion
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Implication
Bamiphylline abolishes ischemic preconditioning during angioplasty; confirms A1 adenosine receptor mediation in humans and cautions against such blockade in ischemia.
Structured PICO
Does bamiphylline abolish ischaemic preconditioning in patients undergoing single-vessel coronary angioplasty?
P
Population
36 consecutive patients undergoing single-vessel coronary angioplasty
I
Intervention
Intravenous infusion of bamiphylline (5 mg/kg) immediately prior to the procedure
C
Comparator
Intravenous infusion of placebo (0.9% NaCl) immediately prior to the procedure
O
Outcome
Mean values of ST segment shifts on the surface and intracoronary electrocardiograms at the end of the first and second balloon inflations (both 2 min long)surrogate
Blockade of A1 adenosine receptors with bamiphylline abolishes ischaemic preconditioning during coronary angioplasty in humans, suggesting the process is mediated by these receptors.
Cite This Study
Tomai et al. (1996) studied this question.