Key result
Electroacupuncture at PC6 reduced stress-induced increases in cardiac sympathetic activity, plasma catecholamines, CRH, and cortisol in rats, whereas electroacupuncture at the tail had no effect.
Why the study?
Stress can trigger cardiovascular disease via autonomic imbalance and increased neurohormonal output, and PC6 is used to treat cardiovascular disease and improve stress-related activities.
Does electroacupuncture at PC6 reduce stress-induced autonomic and neuroendocrine responses in rats?
Does electroacupuncture at PC6 reduce stress-induced autonomic and neuroendocrine responses in rats?
Electroacupuncture at PC6 mitigates stress-induced autonomic imbalance and neuroendocrine responses in a rat model, suggesting a potential mechanism for cardiovascular protection.
EA at PC6 may ease stress-induced autonomic and neurohormonal imbalance; leaves open whether it alters cardiovascular outcomes.
Stress can trigger cardiovascular disease. Both imbalance of autonomic nervous activity and increase of neurohormonal output are core aspects of stress responses and can lead to cardiovascular disease. PC6 as a very important acupoint is used to prevent and treat cardiovascular disease and to improve stress-related activities. We examined the influence of electroacupuncture (EA) at PC6 on stress-induced imbalance of autonomic nervous activity and increase of neurohormonal output. EA at PC6 relieved increased cardiac sympathetic nervous activity and decreased cardiac vagal nervous activity induced by immobilization stress. Also, EA at PC6 reduced immobilization stress-induced increases of plasma norepinephrine (NE) and adrenaline (E) released from sympatho-adrenal-medullary axis. Finally, EA at PC6 reduced immobilization stress-induced increases of corticotropin-releasing hormone (CRH) in paraventricular hypothalamic nucleus and plasma cortisol (CORT) released from hypothalamic-pituitary-adrenal axis. However, EA at tail had no significant effect on the stress-induced autonomic and neuroendocrine responses. The results demonstrate the role of EA at PC6 regulating the autonomic and neuroendocrine responses induced by stress and provide insight into the prevention and treatment of EA at PC6 for stress-induced cardiovascular disease by targeting autonomic and neuroendocrine systems.
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Ye et al. (2023) studied Stress-induced autonomic and neuroendocrine responses. Electroacupuncture at PC6 vs. Electroacupuncture at tail was evaluated on Autonomic nervous activity and neurohormonal output. Electroacupuncture at PC6 reduced stress-induced increases in cardiac sympathetic activity, plasma catecholamines, CRH, and cortisol in rats, whereas electroacupuncture at the tail had no effect.
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