Why the study?
Which method of volume standardization is most accurate for comparing isovolumic cardiac function in isolated hearts of varying sizes?
Population
Isolated control hearts of varying sizes with similar papillary muscle function, and hearts with concentric…
Comparison
Five different methods to standardize volume vs Comparison among the five standardization methods
Design
Preclinical
Authors
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May refine isovolumic function comparisons in animal models; leaves open clinical translation.
Which method of volume standardization is most accurate for comparing isovolumic cardiac function in isolated hearts of varying sizes?
Standardizing volume at a set diastolic pressure (10 mmHg) or at 50% of volume at peak developed pressure provides the most accurate comparison of isovolumic cardiac function among isolated hearts of different sizes.
Strömer et al. (1997) studied this question.
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