Copper‐catalyzed one‐pot synthesis of propargylamines via CH activation in PEG

An efficient and convenient three‐component A3 coupling reaction of aldehyde, amine and alkyne via CH activation with CuI alone as the catalyst in PEG is developed, providing a wide range of propargylamines with yields ranging from moderate to excellent. Additionally, the catalyst system was recovered and reused several times without evident loss in activity.