Effect of Vitamin E versus Vitamin C Application on Wound Healing in the Gingival Depigmentation Procedure: A Split-mouth Clinical Comparative Study

Aim: The aim of this study was to evaluate the clinical efficacy of Vitamin E and C application on healing after the gingival depigmentation (GD) procedure. Materials and Methods: A split-mouth study was planned for subjects with gingival melanin hyperpigmentation in maxillary and/or mandibular arches. Each site was randomly divided into two groups. The scalpel surgical technique for depigmentation was performed under local anesthesia. After the depigmentation procedure, Vitamin E was applied in Group 1, and Vitamin C was applied in Group 2. The healing index and Visual Analog Scale scores for pain were recorded on the 15 th day and the 45 th day postoperatively. Results: There was a statistically significant reduction in Visual Analog Scale scores and improvement in healing in both groups on the 15 th day. Subjects in the Vitamin E showed better healing and reduced pain on the 15 th day as compared to Vitamin C, but at the 45 th day, there was no significant difference in both groups. Conclusion: Subjects would show faster healing with the use of Vitamin E application after the surgical procedure of GD.