The beauty of silver has been demonstrated in the alkynylation of functionalized aldehydes and ketones. Silver acetylides of alkynyl propiolates undergo addition to carbonyl compounds in the presence of [Cp2ZrCl2] and AgOTf (see scheme) in a reaction that is compatible with both base-sensitive and acid-sensitive functional groups. Tf=trifluoromethanesulfonyl.
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Shahi et al. (2004) studied this question.
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