Answers are grounded in this paper and cite their sources.
But how does it smell? Theory and experiment support the notion that “deantiaromatization” can serve as a driving force in the 8-π-electron electrocyclization of a cyclopentadienone (see scheme; TEA=triethylamine; TFE=trifluoroethanol). The reaction proceeds in synthetically useful yields and could be applicable to the synthesis of the antiviral agent hamigeran B.
No takes yet. Share an insight, caveat, or question.
Harmata et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: