Synergy is a regulatory phenomenon that controls theexpression of many eukaryotic genes. There are two interrelated manifestations of synergy: the greater than additive effect of increasing numbers of sites on promoteractivity and the cooperative or sigmoidal transcriptionalresponse to increasing concentrations of activator. Theformer effect is the basis of combinatorial control, and thelatter allows genes to be turned on and off over smallchanges in activator concentration, providing a sensitivemolecular switch...
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Ellwood et al. (1998) studied this question.
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