Summary The preparation of rabbit immune globulins from tissue cultures of human skin cells and whole human placenta is described. An assay of the cytopathogenic effect of the anti-skin immune globulin demonstrated a profound activity against human cells of ectodermal and mesodermal origin. No effect on mouse liver epithelium and mouse subcutaneous (strain L) cells was found. A selective cytotoxicity was demonstrated by the anti-placental immune globulin in vitro. Only fibroblast-like cells were destroyed in cultures of mixed cells arising from skin. The cytotoxic activity of anti-skin globulin could be effectively inhibited by the presence of chicken plasma or pooled, frozen, human serum.
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Bassett et al. (1957) studied this question.