Failure of Ketoconazole Treatment of Blastomyces dermatidis Due to Interaction of Isoniazid and Rifampin

Letters and Corrections15 November 1988Failure of Ketoconazole Treatment of Blastomyces dermatidis Due to Interaction of Isoniazid and RifampinSandra Abadie-Kemmerly, MD, George A. Pankey, MD, Joseph R. Dalvisio, MDSandra Abadie-Kemmerly, MDSearch for more papers by this author, George A. Pankey, MDSearch for more papers by this author, Joseph R. Dalvisio, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-10-844 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Rifampin is known to influence the hepatic metabolism of several drugs through stimulating hepatic enzymes. The concomitant administration of rifampin, isoniazid, and ketoconazole has been reported to result in decreased serum levels of all three drugs (1, 2). We report a case of progressive Blastomyces dermatiditis bone infection in a patient with pulmonary tuberculosis and blastomycosis who was receiving antifungal and antituberculous therapy.A 55-year-old woman with diabetes (type II) was treated forMycobacterium tuberculosisandB. dermatiditispneumonia, and respiratory insufficiency with amphotericin B, isoniazid, rifampin, and pyridoxine. Hypoxemia improved, and the chest roentgenogram was clear...References1. Meunier-CarpentierHeymansSnoeckTaterman FCRJ. Interaction of rifampin with ketoconazole and Bayer n7133 in normal volunteers. ICAAC. 1983:981. Google Scholar2. EngelhardStutmanMarks DHM. Interaction of ketoconazole with rifampin and isoniazid [Letter]. N Engl J Med. 1984;311:1681-3. CrossrefMedlineGoogle Scholar3. . Treatment of blastomycosis and histoplasmosis with ketoconazole. Ann Intern Med. 1985;103:861-72. LinkGoogle Scholar4. Cravens P. Interaction of ketoconazole with rifampin and isoniazid [Letter]. N Engl J Med. 1985;312:1061. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Sandra Abadie-Kemmerly, MD; George A. Pankey, MD; Joseph R. Dalvisio, MDAffiliations: Ochsner Clinic and Alton Ochsner Medical Foundation New Orleans, LA 70121 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKetoconazoleDrug interactions with mitotane by induction of CYP3A4 metabolism in the clinical management of adrenocortical carcinomaPharmiacockinetic Interaction Between Naproxen and RifampicinClinically Significant Interactions with Drugs Used in the Treatment of TuberculosisComparative Pharmacokinetics and Pharmacodynamics of the Rifamycin AntibacterialsEffects of the Antifungal Agents on Oxidative Drug MetabolismIsoniazid Drug and Food InteractionsIsoniazid Drug and Food InteractionsUpdate on Drug Interactions with Azole Antifungal AgentsDrug Interactions with Antimicrobial AgentsUpdate on Invasive CandidiasisTreatment and experimental therapeutics of blastomycosisCase Report: I reatment of Blastomycosis with FluconazoleCorrection: Ketoconazole Treatment for Blastomyces dermatitidis InfectionDrugs used in tuberculosis and leprosy 15 November 1988Volume 109, Issue 10Page: 844-845KeywordsAntifungalsBlastomycesDrug metabolismDrugsIsoniazidPyridoxineRespiratory failureThoraxTuberculosisType 2 diabetes ePublished: 1 December 2008 Issue Published: 15 November 1988 PDF downloadLoading ...