A novel NMR experiment used in the undergraduate physical chemistry laboratory is described. This 23 Na NMR experiment allows students to accurately measure the thermodynamic equilibrium constant for the complexation of sodium ions by 18–crown–6. The use of 23 Na NMR is relatively simple for the students to set up and it gives them an opportunity to use multinuclear NMR techniques and to apply them to a Nobel Prize winning concept. Concepts such as noncovalent interactions, Heisenberg line broadening, quadrupole nuclei, linear regression analysis, chemical shielding, and solution equilibrium thermodynamics are also demonstrated.
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Peters et al. (2004) studied this question.