Previous evidence indicated that frog virus 3 (FV3), an icosahedral DNA virus, replicates exclusively in the cytoplasm. However, data presented here demonstrate that FV3 does not replicate in UV-irradiated or enuleated chicken embryo or BSC-1 cells and that virus-specific DNA synthesis is not initiated in such cells. Primary transcription was not detected in infected enucleated cells. These results demonstrate that a functional nucleus is essential for FV3 replication.
No takes yet. Share an insight, caveat, or question.
Goorha et al. (1977) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: