Template-assisted nano-patterning of solid surfaces

Protein layers are deposited on the surface of implanted biomaterials. Better understanding of the interaction between the surface protein layers and the biological system would lead to the development of future biomaterials with superior biocompatibilities. Well-organized biorecognizable surfaces can be formed with various template molecules that provide an appropriate spacing for the attachment of recognition groups to the modified surface. Silane coupling reagents, porphyrin thiols, and cyclic peptides are being used as templates to introduce nano-scale patterns on solid surfaces. Synthesis of these templates and characterization of the modified surface are described.