Cephaloridine

Seventy-six patients with suspected or proved bacterial infections were treated with cephaloridine. Of 67 in whom cephaloridine-sensitive organisms were responsible for disease, 58 (86%) showed excellent clinical and bacteriological responses. Many of these individuals had life-threatening infections; 12 had staphylococcal bacteremia and five had bacteremia due to other organisms. Adverse reactions occurred in 27 (35%) of the 76 patients. Minor reactions included allergic phenomena, phlebitis at the site of infusion, nausea and vomiting, and transient leukopenia. More serious reactions occurring in 11 patients were superinfections in three patients, anaphylaxis in two, and reversible renal injury in five; one developed a Coombs' positive hemolytic anemia and profound renal failure. This agent may be responsible for hemolytic anemia and kidney damage in man.