On the basis of evidence presented in this pamphlet, the maximal permissible concentration of toluene in air is put at 200 parts per million for eight hours' exposure. Since some variation in muscular coordination is produced in human subjects at this level, further reductions are indicated wherever specific or unusual accident hazards exist. The authors conclude that toluene is less toxic than benzene in respect to the hemopoietic system and less toxic than carbon tetrachloride on the liver. Other effects were noted, such as pulmonary and kidney irritation, especially on exposure to higher concentrations. Routes of assimilation and excretion are described. If concentrations are held at or below the maximal figures quoted in this report, the authors feel that untoward effects are not to be expected.
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A 1942 study studied this question.