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January 25, 2022mBioOpen Access

Inhibiting Mycobacterium abscessus Cell Wall Synthesis: Using a Novel Diazabicyclooctane β-Lactamase Inhibitor To Augment β-Lactam Action

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Authors

KDKhalid M DousaDNDavid C. NguyenSKSebastian G. Kurz

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Dousa et al. (2022) studied this question.

synapsesocial.com/papers/6a8b008dc716e89f35dece44https://doi.org/10.1128/mbio.03529-21
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibition of the β-Lactamase Bla Mab by Avibactam Improves the In Vitro and In Vivo Efficacy of Imipenem against Mycobacterium abscessus2017 · 98 citations
  2. 2The addition of avibactam renders piperacillin an effective treatment for Mycobacterium abscessus infection in an in vivo model2018 · 19 citations
  3. 3Select β-Lactam Combinations Exhibit Synergy against <i>Mycobacterium abscessus In Vitro</i>2019 · 75 citations
  4. 4Insights into the l , d -Transpeptidases and d , d -Carboxypeptidase of Mycobacterium abscessus: Ceftaroline, Imipenem, and Novel Diazabicyclooctane Inhibitors2020 · 60 citations
  5. 5<i>In Vitro</i> and Intracellular Activity of Imipenem Combined with Tedizolid, Rifabutin, and Avibactam against <i>Mycobacterium abscessus</i>2019 · 69 citations