A new approach for the construction of indoles employing the air- and moisture-stable reagent Cp 2 TiCl 2 is described. The key steps involved are (1) the intermolecular insertion reactions of an olefin and a titanocene-stabilized benzyne complex and (2) the Pd-catalyzed aryl amination reaction. The simplicity and availability of the requisite starting materials give the method a broad scope for the preparation of polysubstituted indoles.
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Aoki et al. (1998) studied this question.
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