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Immune sensitization to isoflurane should be considered as a potential cause of postoperative liver dysfunction, even when other potential causes like gallstones are present.
This report is of a case of a previously fit 65-year-old woman who developed postoperative liver dysfunction following an anaesthetic involving isoflurane. Biliary ultrasound demonstrated gallstones. However, serum antibodies to trifluoroacetylated proteins were detected, suggesting that immune sensitisation to the anaesthetic could have contributed to the impaired liver function.
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Meldrum et al. (1998) studied this question.
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