Why the study?
Does Dichloroisoproterenol alter the cardiac output response to acute anemia in anesthetized dogs?
Does Dichloroisoproterenol alter the cardiac output response to acute anemia in anesthetized dogs?
The increase in cardiac output caused by acute anemia is likely not mediated by adrenergic stimulation of the heart.
Cardiac output rise with acute anemia persists despite beta-blockade in dogs; leaves open non-adrenergic mechanisms for confirmation in other models.
The cardiac output of anesthetized dogs was markedly elevated by the production of severe acute anemia by exchanging dextran for blood. Dichloroisoproterenol, in a dose which completely blocked the positive chronotropic effect of epinephrine and several reflexes, usually had minimal effects on the cardiac output. The cardiac responses to acute anemia were not different in the DCI-treated and the control groups. It is concluded that the effect of acute anemia on cardiac output is probably not mediated by the action of adrenergic substances on the heart.
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C. W. Gowdey (1962) studied this question.
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