Synthesis of O‐Glycopeptiden

Glycosyl halides of 2‐azido‐2‐deoxy‐D‐galactose derivatives can be selectively coupled to α‐glycosides with the hydroxyl groups of L‐serine and L‐threonine derivatives. Using adequate protecting groups further reactions with any amino acid are possible with the obtained carbohydrate amino acid compounds after the deprotection of the N‐ or C‐terminus. Among others examples from the field of glycophorines and interleukine‐2 are described. This method is also suitable for the synthesis of glycopeptides on solid support.