This is the authors' abstract. We don't add key points for this paper.
Recent studies suggest revisions to the SNARE paradigm of membrane fusion. Membrane tethers and/or SNAREs recruit proteins of the Sec 1/Munc18 family to catalyze SNARE assembly into trans-complexes. SNARE-domain zippering draws the bilayers into immediate apposition and provides a platform to position fusion triggers such as Sec 17/α-SNAP and/or synaptotagmin, which insert their apolar “wedge” domains into the bilayers, initiating the lipid rearrangements of fusion.
Answers are grounded in this paper and cite their sources.
No takes yet. Share an insight, caveat, or question.
Wickner et al. (2017) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: