✓ Five patients with fungal meningitis whose therapy had involved intraventricular amphotericin B delivered through an Ommaya reservoir developed chemical arachnoiditis in reaction to the amphotericin B, and staphylococcal colonization of the reservoir. The arachnoiditis was successfully treated by reducing dosage of amphotericin B, and the contamination of the reservoir by its replacement.
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Graybill et al. (1973) studied this question.
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