Designs for estimating the slope of a response surface are considered. Minimization of the variance of the estimated slope maximized over all points in the factor space is taken as the optimality criterion. Optimal designs under the minimax criterion are derived for second- and third-order polynomial regression over spherical regions.
No takes yet. Share an insight, caveat, or question.
Mukerjee et al. (1985) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: