Key result
Autosomal dominant familial muscle cramps of likely neurogenic origin present between ages 10 and 15, peak in severity and enzyme elevation during adolescence, and resolve after age 25.
Describes a familial syndrome of autosomal dominant muscle cramps with adolescent onset and spontaneous resolution after age 25, likely of neurogenic origin.
Avoid unnecessary interventions for self-resolving adolescent cramps; extends hereditary cramp phenotypes but leaves confirmation and genetics open.
A family is described with generalized muscle cramps inherited as an autosomal dominant trait and with maximal expression during adolescence. The age of onset varies between 10 and 15 years. Muscle enzymes are elevated with a peak level between 15 and 25 years. The complaints seem to disappear after the age of 25 years. EMG and muscle biopsies suggest a neurogenic origin of the cramps.
No takes yet. Share an insight, caveat, or question.
Bergh et al. (2008) studied this question. Autosomal dominant familial muscle cramps of likely neurogenic origin present between ages 10 and 15, peak in severity and enzyme elevation during adolescence, and resolve after age 25.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: