Treatment of Adrenocortical Cancer with O,P′-DDD

Article1 July 1963Treatment of Adrenocortical Cancer with O,P′-DDDANTONIO DA SILVA COELHO NETTO, M.D., BERNARDO LÉO WAJCHENBERG, M.D., CASSIO RAVAGLIA, M.D., VIRGILIO GONÇALVES PEREIRA, M.D., JOSÉ SHNAIDER, M.D., ARMANDO AGUIAR PUPO, M.D., ANTONIO BARROS DE ULHOA CINTRA, M.D., PH.D.ANTONIO DA SILVA COELHO NETTO, M.D.Search for more papers by this author, BERNARDO LÉO WAJCHENBERG, M.D.Search for more papers by this author, CASSIO RAVAGLIA, M.D.Search for more papers by this author, VIRGILIO GONÇALVES PEREIRA, M.D.Search for more papers by this author, JOSÉ SHNAIDER, M.D.Search for more papers by this author, ARMANDO AGUIAR PUPO, M.D.Search for more papers by this author, ANTONIO BARROS DE ULHOA CINTRA, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-1-74 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe initial observations of Nelson and Woodward (1, 2) that the feeding of the insecticide, 1,1-dichloro-2,2-bis (p-chlorophenyl) ethane (DDD) to dogs results in necrosis and atrophy of the adrenal cortex opened a new research field for adrenocorticolytic drugs. Brown et al. (3-5) observed that necrosis of the adrenal cortex was followed by a decrease in urinary excretion of 17-hydroxycorticosteroids. In these animals a picture compatible with adrenocortical insufficiency developed which was not modified by the simultaneous administration of adrenocorticotropic hormone (ACTH) but which could be prevented by cortisone.Other authors (6-8) confirmed these initial data and the technical grade DDD...References1. NELSONWOODWARD AAG: Adrenal cortical atrophy and liver damage in dogs feeding 2,2-bis (parachlorophenyl) 1,1-dichloroethane (DDD). Fed. Proc. 7: 276, 1948. Google Scholar2. NELSONWOODWARD AAG: Severe cortical atrophy (cytotoxic) and hepatic damage produced in dogs by feeding 2,2-bis (parachlorophenyl) 1,1-dichloroethane, DDD or TDE. Arch. Path. 48: 387, 1949. Google Scholar3. BROWNGRIFFINSMITH JHJRB: Excretion of urinary 17-hydroxycorticoids in dog fed DDD. Metabolism 4: 542, 1955. MedlineGoogle Scholar4. BROWNSMITHGRIFFINANASONJACOBS JHRBJAJ: Physiologic activity of an adrenocorticolytic drug in the adult dog. Metabolism 5: 595, 1956. Google Scholar5. BROWNSMITHGRIFFINJACOBS JHRBJJ: The influence of cortisone on the action of an adrenocorticolytic drug. Endocrinology 61: 106, 1957. CrossrefMedlineGoogle Scholar6. NICHOLSHENNIGAR JG: Studies on the adrenal during simultaneous administration of DDD and amphenone. Ibid., 226. Google Scholar7. NICHOLSHENNIGAR JG: Studies on DDD, 2,2-bis (parachlorophenyl) 1,1-dichloroethane Exp. Med. Surg. 15: 310, 1957. MedlineGoogle Scholar8. TULLNERJACKSON WWSJ: Pharmacological suppression of adrenal cortical function in dogs treated chemically with amphenone or DDD. Abstract presented at the thirty-ninth meeting of the Endocrine Society, May 30-June 1, 1957, New York. Google Scholar9. CUETOBROWN CJH: Biological studies on an adrenocorticolytic agent and the isolation of the active components. Endocrinology 62: 334, 1958. CrossrefMedlineGoogle Scholar10. VILARTULLNER OWW: Effects of o, p′-DDD on histology and 17-hydroxycorticosteroids output of the dog adrenal cortex. Endocrinology 65: 80, 1959. CrossrefMedlineGoogle Scholar11. BERGENSTALLIPSETTMOYHERTZ DMMBRHR: Regression of adrenal cancer and suppression of adrenal function in man by o, p′-DDD. Trans. Ass. Amer. Physicians 72: 341, 1959. Google Scholar12. BERGENSTALHERTZLIPSETTMOY DMRMBRH: Chemotherapy of adrenocortical cancer with o, p′-DDD. Ann. Intern. Med. 53: 672, 1960. LinkGoogle Scholar13. GALLAGHERFUKUSHIMAHELLMAN TFDKL: The effect of o, p′-DDD on steroid hormone metabolites in adrenocortical carcinoma. Metabolism 11: 1155, 1962. MedlineGoogle Scholar14. VERDONBRUTONHERMANBEISEL TAJRHWR: Clinical and chemical response of functioning adrenal cortical carcinoma to o, p′-DDD. Ibid., 226. Google Scholar15. SOUTHRENWEINSENFELDLAUFERGOLDNER ALSAMG: Effect of o, p′-DDD in a patient with Cushing's syndrome. J. Clin. Endoc. 21: 201, 1961. CrossrefGoogle Scholar16. GEYER G: Erfolgreiche behandlung eines falles von Cushing-syndrom mit o, p′DDD. Acta Endocr. (Kobenhavn) 40: 332, 1962. Google Scholar17. DREKTERHEISLERSCISMSTERNPEARSONMCGAVACK IJAGRSSTH: The determination of urinary steroids. I. The preparation of pigment-free extracts and a simplified procedure for the estimation of total 17-ketosteroids. J. Clin. Endocr. 12: 55, 1952. CrossrefMedlineGoogle Scholar18. BUTTKORNELMORRIS WRLR: The determination of 17-OH corticosteroids in urine. Acta Endocr. (Kobenhavn) 26: 65, 1957. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: São Paulo,From the First Medical Clinics, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil.Requests for reprints should be addressed to Bernardo Léo Wajchenberg, Unidade de Diabetes e Suprarrenal, 1.a Clinica Medica, Hospital das Clinicas da Universidade de São Paulo, Brazil. 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