Population
In vitro factor Xa and trypsin complexes, and in vivo rat model
Comparison
Racemic 4'-amidinobenzenesulfonyl-glycyl-4-amidin… vs Other benzamidine derivatives
Design
Preclinical
Authors
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May inform bis-benzamidine design for fXa inhibition; hypothesis-generating in animals, translation untested.
A novel bis-benzamidine compound demonstrates high affinity for factor Xa, a unique retro-binding mode, and slow plasma clearance in rats, serving as a potential lead structure for new fXa inhibitors.
Gabriel et al. (1998) studied this question.
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