Abstract 3,4‐Dichloro‐2(5H)‐furanone, which has been prepared efficiently from mucochloric acid, has been transformed selectively into 4‐aryl‐3‐chloro‐2(5H)‐furanones either by Suzuki‐ or Stille‐type reactions. These monochloro derivatives have been used as precursors either to (Z)‐4‐aryl‐5‐[1‐(aryl)methylidene]‐3‐chloro‐2(5H)‐furanones, including naturally occurring rubrolide M, or to unsymmetrical 3,4‐diaryl‐2(5H)‐furanones. Some 2(5H)‐furanone derivatives so prepared have been found to exhibit significant cytotoxic activity in vitro against the NCI three‐cell‐line panel, but limited cytotoxicity against the NCI human tumor 60 cell‐line panel. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
No takes yet. Share an insight, caveat, or question.
Bellina et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: