Why the study?
Does isolated mitral stenosis alter left ventricular ejection performance and systolic muscle function compared to normal subjects?
Does isolated mitral stenosis alter left ventricular ejection performance and systolic muscle function compared to normal subjects?
This study aims to clarify the controversial status of systolic left ventricular performance in patients with isolated mitral stenosis by evaluating load-independent indices of contractility.
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Load-independent indices may clarify LV contractility in isolated mitral stenosis; leaves open whether performance is impaired and should not change practice.
The status of systolic left ventricular (LV) performance in patients with isolated mitral stenosis (MS) is controversial. Potential alterations in LV architecture as well as loading conditions may have complex effects on LV ejection performance and muscle function. Therefore, we determined hemody- namic and angiographic LV ejection indexes (ejection fraction [EF], velocity of circumferential fiber shortening [Vcf] and stroke work index [SWI]), the level of preload (end-diastolic volume index [EDVII), afterload (end-systolic wall stress [ESS]), and an index of LV contractile function thought to be independent of loading conditions (end-systolic wall stress/end-systolic volume index [ESS/ESVI]) in nine normal sub- jects and 16 patients with isolated MS.
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Gash et al. (1983) studied this question.
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