Key result
Double-dose vaccination with FMD virus serotype O Manisa vaccine yielded significantly higher mean virus neutralisation titres than single-dose vaccination in commercial cattle herds (2.02 vs 0.90).
Why the study?
The recent introduction of foot-and-mouth disease virus serotype O into Southern Africa changed the disease epidemiology and vaccine requirements of the region.
Does a double-dose schedule of FMD virus serotype O Manisa vaccine improve antibody responses compared to a single-dose schedule in cattle?
Does a double-dose schedule of FMD virus serotype O Manisa vaccine improve antibody responses compared to a single-dose schedule in cattle?
A two-dose primary course of the FMD virus serotype O Manisa vaccine induces significantly higher antibody responses than a single dose in cattle.
Vaccine performance against emerging O/EA-2 remains uncertain; leaves open optimal regimens for Southern African cattle.
The recent introduction of foot-and-mouth disease (FMD) virus serotype O (O/EA-2 topotype) in Southern Africa has changed the epidemiology of the disease and vaccine requirements of the region. Commercial and subsistence cattle herds in Zambia were vaccinated with an FMD virus serotype O Manisa vaccine according to a double- or single-dose vaccination schedule. Heterologous antibody responses induced by this vaccine against a representative O/EA-2 virus from Zambia were determined. Virus neutralisation tests (VNTs) showed double-dosed cattle had a mean reciprocal log virus neutralisation titre of 2.02 (standard error [SE] = 0.16, n = 9) for commercial herds and 1.65 (SE = 0.17, n = 5) for subsistence herds 56 days after the first vaccination (dpv). Significantly lower mean titres were observed for single-dosed commercial herds (0.90, SE = 0.08, n = 9) and subsistence herds (1.15, SE = 0.18, n = 3) 56 dpv. A comparison of these results and those generated by solid-phase competitive ELISA (SPCE) tests showed a statistically significant positive correlation by Cohen's kappa coefficient. Therefore, SPCE might be used in assessing the immunogenicity of vaccines in place of VNT. Furthermore, for this vaccine and field strain, a vaccination regime employing a two-dose primary course and revaccination after 4-6 months is likely to be appropriate.
No takes yet. Share an insight, caveat, or question.
Banda et al. (2023) studied Foot-and-mouth disease (n=26). FMD virus serotype O Manisa vaccine vs. Single-dose was evaluated on Mean reciprocal log virus neutralisation titre at 56 days post-vaccination in commercial herds. Double-dose vaccination with FMD virus serotype O Manisa vaccine yielded significantly higher mean virus neutralisation titres than single-dose vaccination in commercial cattle herds (2.02 vs 0.90).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: