What question did this study set out to answer?

To review and evaluate the paradigm shift in AIDS pathogenesis from direct viral cytotoxicity toward chronic immune activation.

September 15, 2003Journal of Clinical InvestigationOpen Access

Turnover of lymphocytes and conceptual paradigms in HIV infection

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Authors

GSGuido SilvestriInternational AIDS Vaccine Initiative MFMark B. FeinbergInternational AIDS Vaccine Initiative

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Implication

Mechanistic analysis reveals elevated effector-memory T cell proliferation in HIV-infected individuals, indicating chronic immune activation drives AIDS pathogenesis.

Key Points

To review and evaluate the paradigm shift in AIDS pathogenesis from direct viral cytotoxicity toward chronic immune activation.
Evaluated mechanistic models explaining CD4+ T-cell loss during HIV infection.
Assessed lymphocyte turnover rates and subset-specific cellular dynamics, focusing on effector-memory T cells.
Elevated T-cell turnover observed in HIV infection predominantly reflects increased proliferation of effector-memory T cells rather than naive T cells.
Evidence qualitatively indicates that generalized chronic immune activation plays a primary role in the progressive pathogenesis of AIDS.

Cite This Study

Silvestri et al. (2003) studied this question.

synapsesocial.com/papers/6a8b17e60ca85c7e33dedd98 https://doi.org/10.1172/jci19799

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Implication

Mechanistic analysis reveals elevated effector-memory T cell proliferation in HIV-infected individuals, indicating chronic immune activation drives AIDS pathogenesis.

Turnover of lymphocytes and conceptual paradigms in HIV infection

Discussion

Member takes

Implication

Key Points

Cite This Study

Turnover of lymphocytes and conceptual paradigms in HIV infection

Discussion

Member takes

Implication

Key Points

Cite This Study

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