Vascular permeability factor increases blood-brain barrier permeability exclusively from the abluminal side, suggesting localized receptor distribution.
Hypothesis-generating for side-specific VPF targeting in CNS models; leaves open translation to human neurovascular disease.
The effects of vascular permeability factor (VPF) on the blood-brain barrier (BBB) permeability were studied in cultured capillary endothelial cells from bovine brain. When VPF was added to the abluminal or brain side of the BBB, a rapid increase in the BBB permeability was observed. This increase in the BBB permeability is dependent on the concentration of the VPF used and is reversible on removal of the VPF. Contrarily, when VPF was added to the luminal or blood side of the BBB, no increase in the BBB permeability was observed. These results suggest that the receptors for VPF are located on the abluminal side of the BBB.
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Zhang et al. (1998) studied this question.
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