August 1, 1979Journal of General Virology

Correlation of Pathogenicity and Gene Constellation of Influenza A Viruses. III. Non-pathogenic Recombinants Derived from Highly Pathogenic Parent Strains

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Population

Recombinant avian influenza viruses derived from A/FPV/Rostock and A/turkey/England/63 tested in chickens…

Comparison

Recombination of two highly pathogenic avian… vs Parent strains

Design

Preclinical

Authors

RRR. RottUnited States Department of Health and Human Services MOMichaela OrlichJustus-Liebig-Universität Gießen CSChristoph ScholtissekJustus-Liebig-Universität Gießen

Discussion

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Implication

Polymerase origin may predict recombinant avian influenza pathogenicity in chickens; leaves open translation to mammalian models or vaccines.

Structured PICO

Population

Recombinant avian influenza viruses derived from A/FPV/Rostock (Hav1N1) and A/turkey/England/63 (Hav1Nav3) tested in chickens and chick embryo cells

Intervention

Recombination of two highly pathogenic avian influenza viruses

Comparator

Parent strains

Outcome

Pathogenicity for chickens and genetic analysis of RNA polymerase complex

The pathogenicity of recombinant avian influenza viruses in chickens correlates with the origin of their RNA polymerase complex genes rather than their biological properties.

Cite This Study

Rott et al. (1979) studied this question.

synapsesocial.com/papers/6a8b1ef0eada60f85de3b4f1 https://doi.org/10.1099/0022-1317-44-2-471

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Implication

Polymerase origin may predict recombinant avian influenza pathogenicity in chickens; leaves open translation to mammalian models or vaccines.

Correlation of Pathogenicity and Gene Constellation of Influenza A Viruses. III. Non-pathogenic Recombinants Derived from Highly Pathogenic Parent Strains

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Correlation of Pathogenicity and Gene Constellation of Influenza A Viruses. III. Non-pathogenic Recombinants Derived from Highly Pathogenic Parent Strains

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider