Key result
Therapeutic plasma exchange significantly reduced mean triglyceride levels by 69.7% (from 3132 mg/dL to 948 mg/dL, P < 0.001) in patients with hypertriglyceridemic pancreatitis.
Why the study?
High triglyceride levels are associated with increased cardiovascular disease, hepatic steatosis, and acute pancreatitis, an entity with high mortality for which therapeutic plasma exchange is a rapid modality.
Does therapeutic plasma exchange reduce triglyceride levels in patients with severe hypertriglyceridemia and pancreatitis?
Observational (n=31)
No
Does therapeutic plasma exchange reduce triglyceride levels in patients with severe hypertriglyceridemia and pancreatitis?
Therapeutic plasma exchange is a fast and effective modality that reduces triglyceride levels by approximately 70% in patients with severe hypertriglyceridemia.
Background/aim: High triglyceride (TG) levels are associated with increases in atherosclerotic cardiovascular disease (CVD), hepatic steatosis, and pancreatitis. Acute pancreatitis is a condition with high mortality. Therapeutic plasma exchange (TPE) in the treatment of hypertriglyceridemic pancreatitis (HTGP) is a rapid and effective treatment modality. In this study, the results of TPE were evaluated and the frequency of lipoprotein lipase (LPL) mutation in these patients was determined. Materials and methods: TPE was performed in 31 patients with HTGP at the Adult Therapeutic Apheresis Center. Results: A TG level under 500 mg/dL was achieved by applying apheresis at a median of 2 times (IQR 2–2, min 1, max 6) in the 31 cases. LPL mutation was detected in 8 (25.8%) of the 31 hypertriglyceridemia cases. When TG levels before and after TPE were evaluated, the mean TG level before TPE was significantly higher (3132 ± 1472 mg/dL) than the mean TG level afterwards (948 ± 465 mg/dL, P < 0.001). This result represented a decrease of 69.7% TG after TPE. Conclusion: TPE is a safe, fast, and effective treatment modality in experienced centers.
No takes yet. Share an insight, caveat, or question.
Şimşir et al. (2019) conducted an observational in Hypertriglyceridemic pancreatitis (n=31). Therapeutic plasma exchange vs. Baseline (before TPE) was evaluated on Mean triglyceride level (69.7% decrease, p=<0.001). Therapeutic plasma exchange significantly reduced mean triglyceride levels by 69.7% (from 3132 mg/dL to 948 mg/dL, P < 0.001) in patients with hypertriglyceridemic pancreatitis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: