Key result
Patients with gastroesophageal reflux disease had significantly lower mean serum cholinesterase activity (5,445 IU/L) compared to healthy individuals (6,728 IU/L).
Why the study?
Acetylcholine helps reduce inflammation, and decreasing cholinesterase increases acetylcholine, prompting investigation into cholinesterase activity in patients with GERD.
Is serum cholinesterase activity altered in patients with gastroesophageal reflux disease compared to healthy individuals?
Cross-Sectional (n=60)
No
Is serum cholinesterase activity altered in patients with gastroesophageal reflux disease compared to healthy individuals?
Answers are grounded in this paper and cite their sources.
Serum cholinesterase activity is significantly reduced in patients with GERD and may serve as a potential diagnostic biomarker.
Background: Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal diseases. One of the factors that are known to play a role in reducing inflammation is acetylcholine (Ach), which decreases cholinesterase to increase Ach. The present study investigated cholinesterase activity in the serum of patients with GERD. Methods: In this cross-sectional study, 30 patients with GERD were referred to Imam Reza Hospital, and 30 healthy individuals were included in the study. Serum was collected in the morning and the fasting state. Cholinesterase activity was measured photometrically and analyzed by unpaired student t-test and receiver operating characteristic (ROC) curve analysis. Results: The mean serum cholinesterase activity was significantly lower in the GERD group (5,445 ± 411 IU/L) than in healthy individuals (6,728 ± 305 IU/L). The cut-off for the detection of patients suffering from GERD by the serum activity of cholinesterase was 5,637 IU/L. Conclusions: It seems that the cholinesterase activity reduces in the serum of patients with GERD.
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Mirzaii-Dizgah et al. (2022) conducted a cross-sectional in Gastroesophageal Reflux Disease (GERD) (n=60). Gastroesophageal Reflux Disease (GERD) vs. Healthy individuals was evaluated on Mean serum cholinesterase activity (IU/L) (p=0.001). Patients with gastroesophageal reflux disease had significantly lower mean serum cholinesterase activity (5,445 IU/L) compared to healthy individuals (6,728 IU/L).
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