Although the general metabolic effects of gonadal steroids have long been recognized, the mechanisms by which they exert these effects are as yet poorly understood. Jensen and Tenenbaum, in their 1944 review of endocrine enzyme relationships; noted that there were no reports on the relations of these hormones to specific enzyme systems in vitro. Since that time Kochakian has extensively studied the effects of castration and of various steroids upon the acid and alkaline phosphatases and arginases in several tissues (Kochakian, 1947). On the basis of these studies Kochakian (1946) has suggested that kidney arginase may be associated with the protein-anabolic properties of the steroids. Clark, Kochakian, and Fox (1943) have found that testosterone increases the d-amino acid oxidase of the mouse kidney. Kochakian (1943) has also showed a similar increase in the activity of this enzyme in liver. Everett and Sawyer (1946) have found that testosterone lowers the serum content of non-specific cholinesterase in the rat.
No takes yet. Share an insight, caveat, or question.
Eisenberg et al. (1949) studied this question.