When the chips are down: A stable zeolite nanocrystal matrix accommodating trypsin has been constructed on a microfluidic chip as a bioreactor to favor highly efficient proteolysis (see picture). The whole procedure is rapid and easily manipulated, thus providing a promising way to solve low-efficiency digestion in advancing the development of proteomics. PMMA=poly(methyl methacrylate).
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Zhang et al. (2006) studied this question.
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