Molecular determinants of external barium block in Shaker potassium channels
Population
Shaker K+ channels
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Findings on Shaker K+ residues should not yet alter clinical blocker use; extends models of external Ba2+ binding in Kv channels.
Structured PICO
P
Population
Shaker K+ channels
I
Intervention
Mutations in the outer pore region (T449A, V, Y; D447N; W434F)
O
Outcome
External Ba2+ block and gating currentssurrogate
In Shaker K+ channels, D447 contributes to an external Ba2+ binding site while T449 imposes a barrier to the access of that site.
Cite This Study
Hurst et al. (1996) studied this question.