Key result
High body weight variability was associated with a significantly increased risk of rapid progression of coronary artery calcification (adjusted OR 2.602) compared to low body weight variability in patients with predialysis chronic kidney disease.
Why the study?
It was unknown whether high body weight variability is associated with a higher prevalence or more rapid progression of coronary artery calcification in patients with predialysis chronic kidney disease.
Does high body weight variability increase the risk of rapid progression of coronary artery calcification in patients with predialysis chronic kidney disease?
Cohort (n=1,162)
Yes
Does high body weight variability increase the risk of rapid progression of coronary artery calcification in patients with predialysis chronic kidney disease?
Odds Ratio: 2.602 (95% CI 1.304–5.191)
p-value: p=0.007
High body weight variability is independently associated with rapid progression of coronary artery calcification in patients with predialysis chronic kidney disease, even in the absence of significant overall weight gain or loss.
High BWV was associated with CAC progression in predialysis CKD; hypothesis-generating, prospective trials needed before practice change.
BACKGROUND: We investigated whether high body weight variability (BWV) is associated with a higher prevalence of coronary artery calcification (CAC) or more rapid progression of CAC in patients with predialysis chronic kidney disease (CKD). METHODS: A total of 1,162 subjects from a nationwide prospective cohort of predialysis CKD were analyzed. The subjects were divided into the tertile (T1, T2, and T3) by BWV. CAC was assessed at the baseline and a 4-year follow-up by CT scan. Rapid progression of coronary artery calcification was defined as an increase in coronary artery calcium score (CACS) more than 200 Agatston units during a 4-year follow-up. RESULTS: One-way ANOVA revealed that CACS change during the follow-up period is significantly higher in the subjects with high BWV, although CACS at the baseline and 4-year follow-up was not different among the tertile groups by BWV. Logistic regression analysis revealed that compared to low BWV (T1), both moderate (T2, adjusted odds ratio (OR) 2.118, 95% CI 1.075-4.175) and high (T3, adjusted OR 2.602, 95% CI 1.304-5.191) BWV was associated with significantly increased risk of rapid progression of CAC. Importantly, the association between BWV and progression of CAC remained robust even among the subjects without significant BW gain or loss during follow-up periods (T2, adjusted OR 2.007, 95% CI 1.011-3.984; T3, adjusted OR 2.054, 95% CI 1.003-4.207). CONCLUSION: High BWV is independently associated with rapid progression of CAC in patients with predialysis CKD.
No takes yet. Share an insight, caveat, or question.
Suh et al. (2022) conducted a cohort in Predialysis chronic kidney disease (n=1,162). High body weight variability vs. Low body weight variability was evaluated on Rapid progression of coronary artery calcification (increase in CACS > 200 Agatston units during a 4-year follow-up) (adjusted OR 2.602, 95% CI 1.304-5.191, p=0.007). High body weight variability was associated with a significantly increased risk of rapid progression of coronary artery calcification (adjusted OR 2.602) compared to low body weight variability in patients with predialysis chronic kidney disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: