The Determinants of Cerebrospinal Fluid PO2

Article1 January 1966The Determinants of Cerebrospinal Fluid PO2The Effects of Oxygen and Carbon Dioxide Breathing in Patients with Chronic Lung DiseaseRAMON S. DUNKIN, M.D., STUART BONDURANT, M.D.RAMON S. DUNKIN, M.D., STUART BONDURANT, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-1-71 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhile hypoxia and hypercapnia usually cause a decrease in cerebral vascular resistance, cerebral oxygen consumption is little changed except under extreme conditions. The effect of these changes on cerebral PO2is uncertain because of technical difficulties with the measurement of tissue PO2and because there are apparently extracellular and intracellular regional differences in PO2. Changes in cerebrospinal fluid (CSF) PO2must be due to changes in the PO2of that part of the system with which CSF is in equilibrium or due to equilibration with a different part of the system under the altered conditions. The present study was designed...References1. KRUMHOLZCHEVALIERROSS RARBJC: Cardiopulmonary function in young smokers. A comparison of pulmonary function measurements and some cardiopulmonary responses to exercise between a group of young smokers and a comparable group of non-smokers. Ann. Intern. Med. 60: 603, 1964. LinkGoogle Scholar2. SEVERINGHAUS JW: Oxyhemoglobin dissociation curve correction for temperature and pH variation in human blood. J. Appl. Physiol. 12: 485, 1958. CrossrefMedlineGoogle Scholar3. HICKAMFRAYSER JBR: Spectrophotometric determination of blood oxygen. J. Biol. Chem. 180: 457, 1949. CrossrefMedlineGoogle Scholar4. SNEDECOR GW: Statistical Methods. Iowa State University Press, Ames, Iowa, 1956. Google Scholar5. 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DUNKIN, M.D.; STUART BONDURANT, M.D.Affiliations: Indianapolis, IndianaFrom the Department of Medicine, Indiana University Medical Center, Indianapolis, Ind.This study was supported in part by research grant H-4080 from the National Heart Institute, National Institutes of Health, training grant HE 5363 from the National Institutes of Health, Bethesda, Md., American Heart Association research grant 62G137, and in part by U. S. Air Force contract 33(616) 8378. Facilities for these studies were provided in part by grant HE 06308, U. S. Public Health Service, Bethesda, Md.Dr. Dunkin performed this work during the tenure of a U. S. Public Health Service fellowship.Requests for reprints should be addressed to Stuart Bondurant, M.D., Indiana University Medical Center, 1100 W. Michigan St., Indianapolis, Ind. 46207. 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