Key result
Perioperative methylprednisolone was not associated with any mortality or length-of-stay benefit compared to no steroids in neonates undergoing heart surgery, but increased infection risk.
Why the study?
Does perioperative methylprednisolone reduce mortality or length-of-stay in neonates undergoing heart surgery?
Cohort
Does perioperative methylprednisolone reduce mortality or length-of-stay in neonates undergoing heart surgery?
Perioperative methylprednisolone does not improve mortality or length of stay in neonates undergoing heart surgery and may increase the risk of infection.
Recent studies have called into question the benefit of perioperative corticosteroids in children undergoing heart surgery, but have been limited by small sample size, the lack of placebo control, and the grouping of various steroid regimens together in analysis. WHAT THIS STUDY ADDS:We evaluated outcomes across methylprednisolone regimens versus no steroids in a large cohort of neonates and found no mortality or length-of-stay benefit associated with any regimen, and a higher risk of infection in certain subgroups.
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A 2012 study conducted a cohort in Heart surgery. Perioperative methylprednisolone vs. No steroids was evaluated on Mortality or length-of-stay. Perioperative methylprednisolone was not associated with any mortality or length-of-stay benefit compared to no steroids in neonates undergoing heart surgery, but increased infection risk.
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