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The effect of puromycin aminonucleoside (PAN), an inhibitor of enzyme synthesis, on gluconeogenesis in rat liver slices has been investigated. It was found that PAN impaired hepatic carbohydrate synthesis from endogenous precursors and that this effect was overcome by adding L-alanine to the medium as substrate. PAN also greatly reduced the increased gluconeogenesis which is induced by adrenal cortical hormones in vitro. These observations support the postulate that the effect of corticosteroids on carbohydrate formation in liver depends on new enzyme synthesis. (Endocrinology76: 191, 1965)
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Eisenstein et al. (1965) studied this question.
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